abstract：:This study examined the effects of a novel orally active 14,15-epoxyeicosatrienoic acid analog (EET-A) on blood pressure (BP) and myocardial infarct size (IS) in two-kidney, one-clip (2K1C) Goldblatt hypertensive rats during sustained phase of hypertension. Between days 31 and 35 after clip placement the rats were tre...

journal_title：Vascular pharmacology

authors： Alánová P,Husková Z,Kopkan L,Sporková A,Jíchová Š,Neckář J,Imig JD,Klevstig M,Kolář F,Rami Reddy N,Falck JR,Sadowski J,Nishiyama A,Kramer HJ,Melenovský V,Červenková L,Kujal P,Vernerová Z,Červenka L

更新日期：2015-10-01 00:00:00

abstract：:Norepinephrine (NE) responses are larger in renal and femoral veins compared to phenylephrine (PE). These differences may be due to the subtypes of adrenoceptor involved in these responses or to the involvement of local modulatory mechanisms. Therefore, the present study investigated in organ bath the adrenoceptor sub...

journal_title：Vascular pharmacology

authors： de Souza Rossignoli P,Yamamoto FZ,Pereira OC,Chies AB

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:In patients with familial combined hyperlipidemia (FCHL), without metabolic syndrome (MS), occurrence of non-alcoholic fatty liver disease (NAFLD) is related to a specific pro-inflammatory profile, influenced by genetic traits, involved in oxidative stress and adipokine secretion. Among FCHL or MS patients, h...

journal_title：Vascular pharmacology

authors： Santilli F,Blardi P,Scapellato C,Bocchia M,Guazzi G,Terzuoli L,Tabucchi A,Silvietti A,Lucani B,Gioffrè WR,Scarpini F,Fazio F,Davì G,Puccetti L

更新日期：2015-09-01 00:00:00

abstract：:Vasculopathy is common in patients with connective tissue disease and can be directly implicated in the pathogenesis of the disease. Systemic sclerosis is an auto-immune multiorgan connective tissue disorder characterized by fibrosis of the skin and visceral organs and vascular disease. Micro- and macro-vessels are a ...

journal_title：Vascular pharmacology

authors： Kavian N,Batteux F

更新日期：2015-08-01 00:00:00

abstract：:Cardiovascular diseases are the major challenge to modern medicine. Intervention to cardiovascular cells is crucial for treatment of the diseases. Here we report a novel intervention to vascular smooth muscle (VSM) cells by optogenetics. Channelrhodopsin in a tandem with YFP was selectively expressed in smooth muscle ...

journal_title：Vascular pharmacology

authors： Wu Y,Li SS,Jin X,Cui N,Zhang S,Jiang C

更新日期：2015-08-01 00:00:00

abstract：:The aim of this study was to investigate the relation between endothelial dysfunction and aspirin response in a young healthy population (102 men aged 18-40). Initial concentrations of the NO pathway metabolites (ADMA, l-arginine, SDMA), cardiovascular risk markers, oxidative stress markers (MDA, thiol index), sICAM1,...

journal_title：Vascular pharmacology

authors： Doroszko A,Szahidewicz-Krupska E,Janus A,Jakubowski M,Turek A,Ilnicka P,Szuba A,Mazur G,Derkacz A

更新日期：2015-04-01 00:00:00

abstract：:The key for the survival of all organisms is the regulation and control of energy metabolism. Thus, several strategies have evolved in each tissue in order to balance nutrient supply with energy demand. Adenosine monophosphate-activated protein kinase (AMPK) is now recognized as a key participant in energy metabolism....

journal_title：Vascular pharmacology

authors： García-Prieto CF,Gil-Ortega M,Aránguez I,Ortiz-Besoain M,Somoza B,Fernández-Alfonso MS

更新日期：2015-04-01 00:00:00

abstract：:Preclinical and clinical studies have suggested that specific subsets of cells isolated from the bone marrow or peripheral blood, collectively named endothelial progenitor cells (EPCs), play an essential role in neovascularization and are biomarkers of atherosclerosis, inversely related to the presence and progression...

journal_title：Vascular pharmacology

authors： Madonna R,De Caterina R

更新日期：2015-04-01 00:00:00

abstract：:An endothelial dysfunction generates a proatherogenic environment characterized by stimulating thrombus formation. Epidemiological studies have provided evidence of a protective role of healthy diets in the prevention of cardiovascular diseases. Hydroxycinnamic acids constitute abundant polyphenols in our diets as the...

journal_title：Vascular pharmacology

authors： Fuentes E,Palomo I

更新日期：2014-12-01 00:00:00

abstract：:Since the discovery of the importance of nitric oxide (NO) to the human body three decades ago, numerous laboratory and clinical studies have been done to explore its potential therapeutic actions on many organs. In the cardiovascular system, NO works as a volatile signaling molecule regulating the vascular permeabili...

journal_title：Vascular pharmacology

authors： Ma S,Ma CC

更新日期：2014-11-01 00:00:00

abstract：:Hypercholesterolemia, is a prominent risk factor for cardiovascular disease (CVD). Undestanding of the biochemical mechanisms that regulate the expression of the low density lipoproteins receptor (LDLR) and the hepatic clearance of LDL cholesterol (LDL-C) paved the way to the statin therapy as the gold standard for CV...

journal_title：Vascular pharmacology

authors： Norata GD,Tibolla G,Catapano AL

更新日期：2014-08-01 00:00:00

abstract：:Bemiparin is a low molecular weight heparin (LMWH) indicated for the acute treatment of deep vein thrombosis with or without pulmonary embolism, for the prophylaxis of venous thromboembolism in surgical and non-surgical patients and for the prevention of clotting in the extracorporeal circuit during hemodialysis. Due ...

journal_title：Vascular pharmacology

authors： Ciccone MM,Cortese F,Corbo F,Corrales NE,Al-Momen AK,Silva A,Zito A,Pinto M,Gesualdo M,Scicchitano P

更新日期：2014-07-01 00:00:00

abstract：:β-Adrenoceptors (β-ARs) modulate ERK1/2 and p38 in different cells, but little is known about the contribution of these signaling pathways to the function of β-ARs in vascular tissue. Immunoblotting analysis of rat aortic rings, primary endothelial (ECs) and smooth muscle cells (SMCs) isolated from aorta showed that β...

journal_title：Vascular pharmacology

authors： Perez-Aso M,Flacco N,Carpena N,Montesinos MC,D'Ocon P,Ivorra MD

更新日期：2014-05-01 00:00:00

abstract：:We previously showed that endothelin A (ETA) receptor antagonist BQ-123 partially inhibited cyclopiazonic acid (CPA)-enhanced endothelin-1 (ET-1)-induced contractions suggesting enhancement of ETA receptor internalization in caveolar structures by sarco/endoplasmic reticulum Ca+2 ATPase (SERCA) blockade. Since seroton...

journal_title：Vascular pharmacology

authors： Selli C,Erac Y,Tosun M

更新日期：2014-05-01 00:00:00

abstract：:Intra-aortic balloon pump (IABP) counterpulsation has been the most widely used left ventricular assist device for nearly five decades. Due to diastolic inflation and systolic deflation, coronary blood flow is increased and afterload decreased translating into augmentation of oxygen supply and lowering of oxygen deman...

journal_title：Vascular pharmacology

authors： de Waha S,Desch S,Eitel I,Fuernau G,Lurz P,Sandri M,Schuler G,Thiele H

更新日期：2014-02-01 00:00:00

abstract：:In this review, we summarize the knowledge pertaining to the role of epigenetics in the regulation of angiogenesis. In particular, we show that lysine acetylation and cytosine methylation are important transcriptional regulators of angiogenic genes in endothelial cells. Lysine acetylation and cytosine methylation inhi...

journal_title：Vascular pharmacology

authors： Shiva Shankar TV,Willems L

更新日期：2014-02-01 00:00:00

abstract：:Numerous studies of acetylcholine (ACh)-induced endothelium-dependent relaxation in arteries have been reported since the original description by Furchgott and Zawadzki (1980). ACh also produces endothelium-independent relaxation. However, it is still unknown whether ACh-induced AMP-activated protein kinase (AMPK) act...

journal_title：Vascular pharmacology

authors： Lee KY,Choi HC

更新日期：2013-09-01 00:00:00

abstract：:Propionyl-l-carnitine (PLC) is a natural short-chain derivative of l-carnitine (LC), a natural amino acid that plays an important role in fatty acid metabolism. Recent studies suggest that PLC has vascular protective effects. Because of the importance of endothelial nitric oxide synthase (eNOS) and its product, antiat...

journal_title：Vascular pharmacology

authors： Ning WH,Zhao K

更新日期：2013-09-01 00:00:00

abstract：:Propranolol is a non-selective beta-adrenergic receptor blocker used in the treatment of cardiovascular diseases and migraine prophylaxis. Although it has been shown that propranolol dilates the peripheral arteries of rat, its action in the central nervous system vasculature has not been investigated. In this study, t...

journal_title：Vascular pharmacology

authors： Cekic EG,Soydan G,Guler S,Babaoglu MO,Tuncer M

更新日期：2013-04-01 00:00:00

abstract：:Angiostatin is an angiogenesis inhibitor in part generated by and released from platelets. Since platelets upon thrombus formation can give rise to areas of hypoxia, we investigated the effects of angiostatin on endothelial cell migration and apoptosis during hypoxia. Human microvascular endothelial cells (HMVEC-L) we...

journal_title：Vascular pharmacology

authors： Radziwon-Balicka A,Ramer C,Moncada de la Rosa C,Zielnik-Drabik B,Jurasz P

更新日期：2013-04-01 00:00:00

abstract：:The objective of this study was to determine the mechanism by which Na(+)/H(+) exchanger (NHE) inhibitors induce vasodilatation. The NHE inhibitors, 5-(N,N-dimethyl)-amiloride (DMA), cariporide, and amiloride, evoked endothelium-dependent relaxation in rat aortas with ED50 values of 16, 89, and 148μM, respectively, an...

journal_title：Vascular pharmacology

authors： Sasahara T,Yayama K,Matsuzaki T,Tsutsui M,Okamoto H

更新日期：2013-04-01 00:00:00

abstract：:In systemic sclerosis, microvascular injury often precedes the development of fibrosis. Whereas the development of digital ulcers and skin fibrosis causes high morbidity, the affection of internal organs, in particular complications such as interstitial lung disease and pulmonary (arterial) hypertension, account for t...

journal_title：Vascular pharmacology

authors： Maurer B,Distler JH,Distler O

更新日期：2013-03-01 00:00:00

abstract：:Angiogenesis has become an attractive target for the treatment of certain diseases such as cancer and rheumatoid arthritis. Our previous studies demonstrated that the saponin fraction from Gleditsia sinensis fruits had anti-angiogenic potential, and Gleditsiosides B (GB) was probably the main active constituent. In th...

journal_title：Vascular pharmacology

authors： Tong B,Lu D,Wei Z,Wang T,Xia Y,Dai Y

更新日期：2013-01-01 00:00:00

abstract：:Despite a large number of studies, the mechanism by which 3',5'-cyclic monophosphate (cAMP) induces vasorelaxation is not fully understood. The comparison between results obtained in different vessels or species has often been the source of conflicting reports. In order to shed more light onto this mechanism, we studi...

journal_title：Vascular pharmacology

authors： Cuíñas A,Elíes J,Orallo F,Campos-Toimil M

更新日期：2013-01-01 00:00:00

abstract：:A small amount of adipose tissue associated with small arteries and arterioles is encountered both in mice and man. This perivascular adipose tissue (PVAT) has a paracrine effect on the vascular tone regulation. PVAT is expanded in obesity and in diabetes. This expansion not only involves enlargement of fat cells, but...

journal_title：Vascular pharmacology

authors： Eringa EC,Bakker W,van Hinsbergh VW

更新日期：2012-05-01 00:00:00

abstract：:Stem cells possess the ability of self-renewal and give rise to specific cell types. The differentiation of stem cells involves environmental factors, transduction of extra and intra-cellular signals, regulation of gene expression by transcriptional factors, microRNAs and chromosome structural modifiers. Vascular SMCs...

journal_title：Vascular pharmacology

authors： Zhang L,Zhou Y,Zhu J,Xu Q

更新日期：2012-05-01 00:00:00

abstract：:Although the vasorelaxing effects of testosterone (T) and various androgen metabolites have been observed in a variety of blood vessels and species, previous studies have not systematically compared the vasorelaxing effects of androgen metabolites in different vascular beds within the same species. Therefore, we studi...

journal_title：Vascular pharmacology

authors： Perusquía M,Espinoza J,Montaño LM,Stallone JN

更新日期：2012-03-01 00:00:00

abstract：:To investigate the vasorelaxant effect of fasudil mesylate (FM) in vivo and in vitro. The relaxation effect of FM was studied using cerebral vasospasm (CVS) model in vivo and isolated aortic rings in vitro. FM (0.35, 1.2, 3.5 mg·kg⁻¹) increased cerebrovascular flow (CVF) and femoral blood flow (FBF) dose-dependently i...

journal_title：Vascular pharmacology

authors： Li Q,Chen Y,Sun L,Fu G,Guo L

更新日期：2011-11-01 00:00:00

abstract：:MicroRNAs (miRNAs) have emerged as crucial players regulating the magnitude of gene expression in a variety of organisms. This class of short (22 nucleotides) noncoding RNA molecules have been shown to participate in almost every cellular process investigated so far, and their deregulation is observed in different hum...

journal_title：Vascular pharmacology

authors： Quintavalle C,Garofalo M,Croce CM,Condorelli G

更新日期：2011-10-01 00:00:00

abstract：:MicroRNAs (e.g., miRNAs), endogenously expressed small non-coding RNAs, control gene expression by regulating target messenger RNA at post-transcriptional level. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. The zebrafish (Danio rerio) system is a ...

journal_title：Vascular pharmacology

authors： Santoro MM

更新日期：2011-10-01 00:00:00

abstract：:Angiogenesis consists in the growth of new blood vessels from pre-existing ones. Although anti-angiogenesis interventions have been shown to have therapeutic properties in human diseases such as cancer, their effect is only partial and the identification of novel modulators of angiogenesis is warranted. Recently, we r...

journal_title：Vascular pharmacology

authors： Yu C,Sharma A,Trane A,Utokaparch S,Leung C,Bernatchez P

更新日期：2011-07-01 00:00:00

abstract：:Evidence from both clinical and experimental studies indicates that Di-peptidyl peptidase-IV (DPP-4) inhibition may mediate favorable effects on the cardiovascular system. The objective of this study was to examine the acute effects of DPP-4 inhibition on vascular responses and to study the underlying mechanisms of al...

journal_title：Vascular pharmacology

authors： Shah Z,Pineda C,Kampfrath T,Maiseyeu A,Ying Z,Racoma I,Deiuliis J,Xu X,Sun Q,Moffatt-Bruce S,Villamena F,Rajagopalan S

更新日期：2011-07-01 00:00:00

abstract：:Our previous studies revealed that scopoletin, the main bioactive constituent of Erycibe obtusifolia Benth stems, exerted anti-arthritic activity in vivo partly by preventing synovial angiogenesis. Herein we further investigated the anti-angiogenic potential and related mechanisms of this coumarin compound in vivo and...

journal_title：Vascular pharmacology

authors： Pan R,Dai Y,Gao XH,Lu D,Xia YF

更新日期：2011-01-01 00:00:00

abstract：:Recent evidence showed that 17 β-estradiol (E₂) decreased cytokine-induced expression of cell adhesion molecules (CAM). Changes in intracellular Ca²+ concentration ([Ca²+](i)) has been shown to be associated with CAM expression in endothelial cells. Here, the effects of E₂ (1 μM, 24 h) on the expression of intracellul...

journal_title：Vascular pharmacology

authors： Thor D,Zhang R,Anderson L,Bose DD,Dubé GP,Rahimian R

更新日期：2010-11-01 00:00:00

abstract：:Doxorubicin (DXR) is a widely used cytostatic agent, but its administration is limited by its cardiovascular side effects. The endothelium is one of the largest organs in the human body and due to its direct contact with blood; it is exposed to the toxic effects of DXR. The aim of this study was to investigate in endo...

journal_title：Vascular pharmacology

authors： Keltai K,Cervenak L,Makó V,Doleschall Z,Zsáry A,Karádi I

更新日期：2010-11-01 00:00:00

abstract：:Endothelial cell dysfunction may play an important role in the development of various vascular diseases, including atherosclerosis. Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a high-fat diet in ApoE⁻/⁻ mice. Te...

journal_title：Vascular pharmacology

authors： Choi SE,Jang HJ,Kang Y,Jung JG,Han SJ,Kim HJ,Kim DJ,Lee KW

更新日期：2010-11-01 00:00:00

abstract：:The sulfur-containing amino acid, taurine, has been shown to ameliorate the vascular disorders. We examined the effects of taurine ingestion on intimal thickening following balloon injury. Balloon injury was induced in the left common carotid artery of Wistar rats. Taurine (3% (w/v)) was mixed in the drinking water fr...

journal_title：Vascular pharmacology

authors： Murakami S,Sakurai T,Toda Y,Morito A,Sakono M,Fukuda N

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS:We studied 27 women treated with paclitaxel-containing combinations...

journal_title：Vascular pharmacology

authors： Vassilakopoulou M,Mountzios G,Papamechael C,Protogerou AD,Aznaouridis K,Katsichti P,Venetsanou K,Dimopoulos MA,Ikonomidis I,Papadimitriou CA

更新日期：2010-09-01 00:00:00

abstract：:Hyperhomocysteinemia (HHcy) is a metabolic disorder marked by an excess amount of the amino acid homocysteine (Hcy) in the blood stream. Hcy is a H(2)S precursor-formed from the metabolism of methionine. Elevated Hcy levels have been associated with higher blood pressure. However, the precise contribution of H(2)S to ...

journal_title：Vascular pharmacology

authors： Sowmya S,Swathi Y,Yeo AL,Shoon ML,Moore PK,Bhatia M

更新日期：2010-09-01 00:00:00

abstract：:Small GTPase Rap1 has been extensively studied in vitro and shown to regulate multiple basic cellular processes. Until recently, the best studied aspect of Rap1 function in endothelial cells involved its role in regulation of cell-cell junction formation and remodeling. These in vitro studies have increased understand...

journal_title：Vascular pharmacology

authors： Chrzanowska-Wodnicka M

更新日期：2010-07-01 00:00:00